Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders

作者：Watanabe Mitsuru; Kondo Takayuki^*; Murakata Kenji; Kageyama Takashi; Shibata Yoko; Takahashi Toshiyuki; Nomura Kyoichi; Matsumoto Sadayuki

来源：Journal of Neuroimmunology, 2014, 274(1-2): 155-160.

DOI：10.1016/j.jneuroim.2014.06.020

• Multiple sclerosis
• Neuromyelitis optica
• CNS demyelinating disorders
• Autoantibodies
• Aquaporin 4
• Contactin-associated protein 2

Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti-N-methyl-D-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis.

• 出版日期2014-9-15