Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

作者：Song, Juan^*; Olsen, Reid H. J.; Sun, Jiaqi; Ming, Guo-li; Song, Hongjun

来源：Cold Spring Harbor Perspectives in Biology, 2016, 8(8): a018937.

DOI：10.1101/cshperspect.a018937

• NEURAL STEM-CELL
• NEWLY GENERATED NEURONS
• ENHANCED SYNAPTIC PLASTICITY
• MEDIAN RAPHE NUCLEUS
• MOUSE DENTATE GYRUS
• SUBVENTRICULAR ZONE
• HIPPOCAMPAL NEUROGENESIS
• NEWBORN NEURONS
• GRANULE CELLS
• PRECURSOR CELLS

The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogenesis, recapitulates neural developmental events in two specialized adult brain regions: the lateral ventricles of the forebrain. Recent studies have begun to delineate how the existing neuronal circuits influence the dynamic process of adult neurogenesis, from activation of quiescent neural stem cells (NSCs) to the integration and survival of newborn neurons. Here, we review recent progress toward understanding the circuit-based regulation of adult neurogenesis in the hippocampus and olfactory bulb.

• 出版日期2016-8
• 单位清华大学