Antifungal Activity of Glycyrrhiza glabra Extracts and its Active Constituent Glabridin

作者:Fatima Atiya; Gupta Vivek K; Luqman Suaib; Negi Arvind S; Kumar J K; Shanker Karuna; Saikia Dharmendra; Srivastava Suchita; Darokar M P*; Khanuja Suman P S
来源:Phytotherapy Research, 2009, 23(8): 1190-1193.
DOI:10.1002/ptr.2726

摘要

Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans at a minimum inhibitory concentration of 31.25-250 mu g/mL. Although the compound was reported earlier to be active against Candida albicans, but this is the first report of its activity against drug resistant mutants.