Abuse potential of carbohydrates for overweight carbohydrate cravers

作者：Spring Bonnie^*; Schneider Kristin; Smith Malaina; Kendzor Darla; Appelhans Bradley; Hedeker Donald; Pagoto Sherry

来源：Psychopharmacology, 2008, 197(4): 637-647.

DOI：10.1007/s00213-008-1085-z

• food addiction
• addictive behavior
• substance-related disorder
• carbohydrate craving
• food preferences
• appetite
• eating
• eating disorder
• women's health
• abuse potential
• abuse liability

Rationale The long-rejected construct of food addiction is undergoing re-examination.
Objectives To evaluate whether a novel carbohydrate food shows abuse potential for rigorously defined carbohydrate cravers, as evidenced by selective self-administration and mood enhancement during double-blind discrimination testing.
Materials and methods Discrete trials choice testing was performed with 61 overweight (BMI m = 27.64, SD = 2.59) women (ages 18-45; 19.70% African American) whose diet records showed > 4 weekly afternoon/evening emotional-eating episodes confined to snacks with carbohydrate to protein ratio of > 6:1. After being induced into a sad mood, participants were exposed, double-blind and in counterbalanced order, to taste-matched carbohydrate and protein beverages. They were asked to choose and self-administer the drink that made them feel better.
Results Women overwhelmingly chose the carbohydrate beverage, even though blinded. Mixed-effects regression modeling, controlling for beverage order, revealed greater liking and greater reduction in dysphoria after administration of the carbohydrate beverage compared to the protein beverage but no differential effect on vigor.
Conclusion For women who crave them, carbohydrates appear to display abuse potential, plausibly contributing to overconsumption and overweight.

• 出版日期2008-5
• 单位西北大学