Detection of virulent strains of Helicobacter pylori and its relation to symptoms and signs in children

作者：Fayed S; Abd El Dayem S^*; Hussein H; Sherief M; El Naghi S

来源：Asian Pacific Journal of Tropical Medicine, 2010, 3(1): 59-62.

DOI：10.1016/s1995-7645(10)60034-x

• Helicobacter pylori
• IgG antibody
• Pediatric
• Gastrointestinal disorder

Objective: To detect the prevalence of Helicobacter polori (H. pylori) in a group of pediatric patients complaining of gastrointestinal disorders, and to identify the virulent strains of H. pylori and its relation to peptic disease. Methods: The study included 60 patients (41 males and 19 females), aged from 6 months to 14 years, with complaining of different gastrointestinal troubles. Anti-H. pylori lgG antibodies were used. Thorough examination of the oesophagus, stomach and duodenum was done in all patients using a fibreoptic endoscopy. In addition, gastric antral biopsies were taken for diagnosis of H. pylori infection in the following test: rapid urease test, histopathologic examination and culture. And cytotoxin assay of virulent strains was employed. H. pylori infection was diagnosed if 3 or more tests for diagnosis were found to be positive. Results: 33 out of 60 patients (55%) was positive. 12 (20%) patients had positive toxin producing strains (virulent strains). Virulent strain had a significantly closer relationship with recurrent abdominal pain, while no difference was found in other symptoms. Age of patients showed a highly significant positive correlation with virulent H. pylori strain. Histopathological finding revealed that oesophagitis was significantly common in patients with negative H. pylori. Endoscopy and histopathological findings revealed that virulent strain had a significantly higher gastritis and oesophagitis rates. Conclusion: Infection by virulent strains of H. pylori in children is not uncommon: It is associated with endoscopic and histopathologic changes. All cases infected with virulent strain showed positive results by using rapid urease test, culture and IgG antibodies.

• 出版日期2010-1