Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes

作者：Miyazawa Taiki; Kamiyoshihara Reina; Shimizu Naoki; Harigae Takahiro; Otoki Yurika; Ito Junya; Kato Shunji; Miyazawa Teruo; Nakagawa Kiyotaka^*

来源：Royal Society Open Science, 2018, 5(2): 171249.

DOI：10.1098/rsos.171249

• Amadori-glycated phosphatidylethanolamine
• curcumin
• glucose transporter
• glycolipid
• liposome
• Maillard reaction product

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

• 出版日期2018-2