Angiography of the ocular fundus without dye: Optical coherence tomography based angiography in exsudative age-related macular degeneration

作者：Miklos Resch; Csilla Nemeth; Gyorgy Barcsay; Monika Ecsedy; Agnes Borbandy; Zsuzsanna Gehl; Aniko Balogh; Antal Szabo; Zsolt Nagy Zoltan; Andras Papp

来源：ORVOSI HETILAP, 2016, 157(42): 1683-1690.

DOI：10.1556/650.2016.30548

<jats:p> Introduction: Vascular endothelial growth factor antibody therapy is an established treatment of exsudative age-related macular degeneration. Aim: The morphologic characterisation of the macular microvasculature after longstanding treatment. Method: Forty-eight patients (34 women and 14 men; age, 74.4 ± 8.0 years) were enrolled in the study. During follow-up time (53.8 ± 31.0 months), 7.6 ± 4.9 injections were administered in 56 eyes. Optical coherence tomography angiographic examination was performed with AngioVue (Optovue Inc. Fremont, CA, USA). Results: Distortion of the superficial retinal plexus and foveal avascular zone enlargement were noted in 5/56 eyes, deep retinal plexus defect was detected in 9/56 cases. Destruction of the choriocapillaries and the former neovascularisation could be found in 4 different patterns: 1. pigment epithelium and choriocapillary atrophy, 2. submacular scar, 3. active leaking choroidal neovascularisation, 4. intraretinal cysts. Conclusion: Optical coherence tomography angiography is a novel non-invasive method, which enables the follow up of macular degeneration. Orv. Hetil., 2016, 157(42), 1683–1690. </jats:p>

• 出版日期2016-10