A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

作者：Jones Emma L^*; Aarsland Dag; Londos Elisabet; Ballard Clive

来源：Neurodegenerative Diseases, 2012, 10(1-4): 229-231.

DOI：10.1159/000334759

• Dementia with Lewy bodies
• Parkinson%26apos
• s disease
• Genetic association
• alpha-Synuclein
• DYRK1A

Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson%26apos;s disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia.

• 出版日期2012