A pneumatic dilation strategy in achalasia: prospective outcome and effects on oesophageal motor function in the long term

作者：Bravi I; Nicita M T; Duca P; Grigolon A; Cantu P; Caparello C; Penagini R^*

来源：Alimentary Pharmacology and Therapeutics, 2010, 31(6): 658-665.

DOI：10.1111/j.1365-2036.2009.04217.x

Background
Long-term follow-up studies of achalasia after pneumatic dilation, mostly retrospective, have shown variable results.
Aim
To examine the outcome of achalasia after pneumatic dilation using a prospective follow-up programme.
Methods
One or two dilations (first dilation treatment) in 77 patients to achieve stable (> 1 year) remission and patients followed up with yearly clinical and manometric assessments. Endoscopy, pH monitoring and barium swallow were also performed.
Results
A total of 69 patients achieved stable remission and were followed up for 5.6 years (3-10.7) [median (IQ range)], whereas six patients underwent cardiomyotomy and two experienced a perforation. Twelve of the 69 patients relapsed after 2.6 years (1.7-5.1): nine of 12 underwent one to two further dilations. Six-year remission rate (by Kaplan-Meyer estimates) was 82% after first dilation treatment and 96% after all dilations. Continuous antisecretory treatment was clinically needed in 16%, oesophagitis present in 7% and reflux pathological in 28% of the patients. Beneficial effects of dilation on oesophageal motility and on diameter of the oesophageal body at barium swallow were maintained during follow-up.
Conclusions
A management strategy including sessions of pneumatic dilation until stable remission and a standardized follow-up is highly successful in the long term. Gastro-oesophageal reflux is clinically relevant in a minority of patients.

• 出版日期2010-3-15