An Efficient and Ecofriendly Three-Component Reaction for the Rapid Synthesis of 2-Amino-4H-chromenes Catalyzed by a DABCO-Based Ionic Liquid

作者：Li, Cheng-Bin; Li, Yu-Wei; Xu, Da-Zhen^*

来源：Synthesis (Germany), 2018, 50(18): 3708-3714.

DOI：10.1055/s-0037-1610123

• 2-amino-4H-chromene
• green chemistry
• ionic liquid
• multicomponent reaction
• salicylaldehyde

An efficient, economical, and green strategy for the construction of biologically relevant 2-amino-4H-chromene scaffolds via a tandem Knoevenagel-Pinner cyclization-Michael reaction has been successfully developed. In the presence of DABCO-based ionic liquids, two different 2-amino-4H-chromene derivatives, 2-amino-4-(indol-3yl)-4H-chromenes and 2-amino-4-(pyrazol-4-yl)-4H-chromenes, were prepared in good to excellent yields (81-97%) within short reaction times under mild conditions. All the products are purified by simple crystallization. The catalyst could be recycled for at least five times.

• 出版日期2018-9
• 单位南开大学