Antiproliferative Evaluation of N-sulfonyl-2-alkyl-six Membered Azacycles. A QSAR Study

作者：Carballo Ruben M; Leon Leticia G; Quijano Quinones Ramiro F; Mena Rejon Gonzalo J; Martin Victor S; Padron Jose M^*; Padron Juan I

来源：Medicinal Chemistry, 2014, 10(6): 571-579.

DOI：10.2174/1573406409666131124231552

• Antiproliferative activity
• aza-cycle
• iron catalyst
• piperidine
• prins cyclization
• QSAR

A series of functionalized N-sulfonyl-piperidines and N-sulfonyl-tetrahydropyridines were evaluated for their antiproliferative activity against the representative panel of human solid tumor cells A2780 (ovarian), SW1573 (non-small cell lung) and WiDr (colon). The SAR study showed for WiDr cells a correlation between the biological activity and the length of the N-sulfonyl group, the nature of the substituents and the type of alkyl side chain. Further QSAR studies indicate that the size and nature of the N-sulfonyl group, the atomic polarizability (MP) and the partition coefficient are the most important descriptors for the activity. The major contribution is the size (F05(C-S)) of the N-sulfonyl group.

• 出版日期2014