Methodology for Removing Dihalomethane Carryover from Solid-Phase Microextraction Fibers

作者：McGuire Christina M; Harrington Edward Jr; Anderson Ashira; Krisch Maria J^*

来源：LC-GC North America, 2016, 34(12): 916-925.

Solid-phase microextraction (SPME) in conjunction with gas chromatography-mass spectrometry (GC-MS) is a simple and effective way to sample analytes. Ordinarily the coated fiber is rid of compounds during desorption in the GC system, allowing for the analysis of a new sample. Carryover of the analyte between samples, however, is a problem with many chemicals. Our data show that heating the fiber in a high-temperature injection port for only 2 min between runs prevents carryover. The short heating between samples improves the linearity of the peak area versus concentration relationship over four orders of magnitude of concentration, with a limit of detection below 10(-7) M in every case. Although carryover is an acknowledged problem with SPME fibers, such short conditioning steps are rarely considered as a means to eliminate it. This study suggests that they should be evaluated as an option.

• 出版日期2016-12