Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice

作者：Van Dien M; Takahashi K; Mu MM; Koide N; Sugiyama T; Mori I; Yoshida T; Yokochi T^*

来源：Microbiology and Immunology, 2001, 45(11): 751-756.

• wogonin
• endotoxin
• tumor-necrosis factor
• endotoxic shock

The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GaIN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GaIN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-alpha. The reduction was more marked in mice injected with D-GaIN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GaIN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-a and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GaIN and LPS is discussed.

• 出版日期2001