Activity induced by dihydrotestosterone-dihydropyrimidine derivative on perfusion pressure and coronary resistance in isolated rat heart

作者：Lauro Figueroa Valverde^*; Francisco Diaz Cedillo; Ma Lopez Ramos; Elodia Garcia Cervera; Karen Quijano A

来源：African Journal of Pharmacy and Pharmacology, 2010, 4(12): 851-859.

• Dihydrotestosterone
• perfusion pressure
• vascular resistance

Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced by dihydrotestosterone and dihydrotestosterone-dihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity exerted by dihydrotestosterone-derivative was characterized. The results showed that dihydrotestosterone-dihydropyrimidine [10(-9) mM] significantly increase the perfusion pressure (p = 0.005) and coronary resistance (p = 0.006) in isolated rat heart. Additionally, the activity exerted by dihydrotestosterone-dihydropyrimidine on perfusion pressure [10(9) to 10(-4) mM] was blocked in the presence of nefidepine [10(-6) mM]. These data suggest that activity induced by dihydrotestosterone-derivative on perfusion pressure and coronary resistance is dependent upon its chemical structure. This phenomenon possibly involves the L-type calcium channel activation through a non-genomic molecular mechanism.

• 出版日期2010-12