A Novel Synthesis of (4aS,7aS)-Octahydro-1H-pyrrolo[3,4-b]pyridine: An Intermediate of Moxifloxacin Hydrochloride

作者：Reddy G Prashanth; Bandichhor Rakeshwar^*

来源：Asian Journal of Chemistry, 2013, 25(15): 8701-8707.

• Nonane
• Racemization
• Naproxen
• Naproxamide
• L-Proline

A novel synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine (1) is demonstrated alongwith recovery and reuse of chiral auxiliary naproxen. Further to this alternative stereoselective reduction procedures on 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 3 enabling the desired chirality in the nonane 1 is demonstrated.

• 出版日期2013-11