Embryonic stem cell-derived neural progenitors transplanted to the hippocampus migrate on host vasculature

作者：Lassiter Chelsea M^*; Gal Julian S; Becker Sandy; Hartman Nathaniel W; Grabel Laura

来源：Stem Cell Research, 2016, 16(3): 579-588.

DOI：10.1016/j.scr.2016.02.043

This study describes the migration of transplanted ESNPs either injected directly into the hippocampus of a mouse, seeded onto hippocampal slices, or under in vitro culture conditions. We show that transplanted mouse ESNPs associate with, and appear to migrate on the surface of the vasculature, and that human ESNPs also associate with blood vessels when seeded on hippocampal slices, and migrate towards BECs in vitro using a Boyden chamber assay. This initial adhesion to vessels is mediated, at least in part, via the integrin alpha 6 beta 1, as observed for SVZ neural progenitor cells. Our data are consistent with CXCL12, expressed by the astroglial vasculature niche, playing an important role in the migration of transplanted neural progenitors within and outside of the hippocampus.

• 出版日期2016-5