Tumor lysis syndrome after treatment with gemcitabine for metastatic transitional cell carcinoma

作者：Lin Cheng Jui; Lim Ken Hong; Cheng Yi Chou; Chen Han Hsiang; Wu Chih Jen^*

来源：Medical Oncology, 2007, 24(4): 455-457.

DOI：10.1007/s12032-007-0014-z

• tumor lysis syndrome
• transitional cell carcinoma
• gemcitabine

Tumor lysis syndrome is a set of life threatening complication that can arise from treatment of high tumor burden, drug sensitive, and rapidly proliferating neoplasm particularly of hematological origin. It is rarely described in patients with solid tumors. We report the first case of tumor lysis syndrome in a man with metastatic renal pelvic transitional cell carcinoma after gemcitabine treatment. Despite aggressive therapy, he died 2 weeks after TLS was diagnosed. Our experience demonstrates that administration of gemcitabine for metastatic renal pelvic transitional cell carcinoma may induce acute tumor lysis syndrome, which necessitates frequent laboratory monitoring and prompt initiation of appropriate therapeutic measures.

• 出版日期2007
• 单位河北医科大学