Phenolic Compounds from Cassia siamea and Their Anti-Tobacco Mosaic Virus Activity

作者:Li, Yin-Ke*; Zhou, Bin; Wu, Xian-Xue; Du, Gang; Ye, Yanqing; Gao, Xue-Mei; Hu, Qiu-Fen
来源:Chemistry of Natural Compounds, 2015, 51(1): 50-53.
DOI:10.1007/s10600-015-1201-3

摘要

Two new phenolic compounds, 6-hydroxy-7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one (1) and 7-hydroxy-6-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one (2), together with six known phenols (3-8), were isolated from the stems of Cassia siamea. The structure of 1-8 was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1-8 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 have potential anti-TMV activity with inhibition rates of 28.2 and 23.5%, respectively. Compounds 3-8 also showed anti-TMV activity with inhibition rates in the range of 11.6-19.8%.