Age and dose-limited PET-CT scan regime in lymphoma: between the devil and the deep blue sea?

作者：Sanghera B^*; Sonoda L I; Hart J; Vivian G; Mills T; Wong W L

来源：Radiation Protection Dosimetry, 2012, 150(3): 381-384.

DOI：10.1093/rpd/ncr412

In this study the authors speculate about hypothetical effective-dose (E) reduction through limiting post-chemotherapy PETCT scanning to lymphoma sites previously identified on pre-treatment CT. E reductions/scan time savings are compared between post-treatment standard and theoretically limited PETCT scans. The influence of patient age with E savings and associated clinical implication for 100 subjects are discussed. The greatest E theoretical savings of 52 and 32 for the CT contribution and combined PETCT, respectively, were seen in patients 18 y old using limited scans in this study, with a potential mean time saving of 16 min per patient across the entire cohort. However, the limited PETCT regime here missed a 1 rate of unexpected cancer that standard PETCT recorded. The authors recommend performing larger scale multi-centre studies comparing PETCT pre- and post-chemotherapy to establish full clinical efficacy of this method.

• 出版日期2012-7