Nature-inspired enzymatic cascades to build valuable compounds

作者：Sigrist Renata; da Costa Bruna Zucoloto; Marsaioli Anita Jocelyne; de Oliveira Luciana Gonzaga^*

来源：Biotechnology Advances, 2015, 33(5): 394-411.

DOI：10.1016/j.biotechadv.2015.03.010

• Chemo- and multi-enzymatic processes
• Polyethers
• Polypeptide alkaloids
• Piperidines and pyrrolidines
• Oxidoreductases
• Hydrolases
• Cyclases
• Transaminases
• Imine reductases

Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases.

• 出版日期2015-10