F-18-choline PET/CT for early detection of metastases in biochemical recurrence following radical prostatectomy

作者：Kjolhede Henrik; Ahlgren Goran; Almquist Helen; Liedberg Fredrik; Lyttkens Kerstin; Ohlsson Thomas; Bratt Ola

来源：World Journal of Urology, 2015, 33(11): 1749-1752.

DOI：10.1007/s00345-015-1547-y

• Prostate cancer
• Recurrence
• Metastasis
• Positron emission tomography
• Computed X-ray tomography

Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of < 1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The purpose was to determine what proportion of a well-defined cohort of hormone-na < ve patients who were candidates for early salvage radiotherapy had F-18-choline PET/CT findings suggesting metastases.
Patients with untreated BCR following RP, PSA < 2 ng/mL, and Gleason score a parts per thousand yen7 or PSA doubling time a parts per thousand currency sign6 months underwent F-18-choline PET/CT. Focal choline uptake in lymph nodes or skeletal sites was recorded.
PET/CT indicated metastases in 16 (28 %) of 58 patients. In five (9 %) patients, the scans suggested bone metastases, and in 11 (19 %) patients, the scans suggested regional lymph node metastases only. For patients with PSA levels < 1.0 ng/mL, the PET/CT scans indicated metastatic recurrence in 25 %.
F-18-choline PET/CT may be valuable for selecting patients with BCR following RP for SRT or experimental treatment of oligometastases, even at low PSA values.

• 出版日期2015-11