BUTYRYLCHOLINESTERASE-KNOCKOUT REDUCES BRAIN DEPOSITION OF FIBRILLAR beta-AMYLOID IN AN ALZHEIMER MOUSE MODEL

作者：Reid G Andrew; Darvesh Sultan^*

来源：Neuroscience, 2015, 298: 424-435.

DOI：10.1016/j.neuroscience.2015.04.039

• Alzheimer's disease
• beta-amyloid
• butyrylcholinesterase
• 5XFAD mouse
• butyrylcholinesterase-knock-out
• cholinergic system

In Alzheimer's disease (AD), numerous beta-amyloid (A beta) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops A beta plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar A beta plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar A beta in AD and this effect may be influenced by sex.

• 出版日期2015-7-9