ANTIPARASITIC ACTIVITY OF DIALLYL TRISULFIDE (DASUANSU) ON HUMAN AND ANIMAL PATHOGENIC PROTOZOA (TRYPANOSOMA SP, ENTAMOEBA-HISTOLYTICA AND GIARDIA-LAMBLIA) IN-VITRO

作者：LUN ZR; BURRI C; MENZINGER M; KAMINSKY R

来源：Annales de la Societe Belge de Medecine Tropicale, 1994, 74(1): 51-59.

• DIALLYL TRISULFIDE (DASUANSU)
• TRYPANOSOMA-B-BRUCEI
• T-B-GAMBIENSE
• TRYPANOSOMA-BRUCEI-RHODESIENSE
• T-EVANSI
• T-EQUIPERDUM
• ENTAMOEBA-HISTOLYTICA
• GIARDIA-LAMBLIA
• DRUG SENSITIVITY
• INCORPORATION TEST IN-VITRO

Garlic (Allium sativum L.) and one of its major components, allicin, have been known to have antibacterial and antifungal activity for a long time. Diallyl trisulfide is a chemically stable final transformation product of allicin which was synthesized in 1981 in China and used for treatment of bacterial, fungal and parasitic infections in man. The activity of diallyl trisulfide was investigated in several important protozoan parasites in vitro. The IC50 (concentration which inhibits metabolism or growth of parasites by 50 %) for Trypanosoma brucei brucei, Tb. rhodesiense, T.b. gambiense, T. evansi, T. congolense and T. equiperdum was in the range of 0.8-5.5 mug/ml. IC50 values were 59 mug/ml for Entamoeba histolytica and 14 mug/ml for Giardia lamblia. The cytotoxicity of the compound was evaluated on two fibroblast cell lines (MASEF, Mastomys natalensis embryo fibroblast and HEFL-12, human embryo fibroblast) in vitro. The maximum tolerated concentration for both cell lines was 25 mug/ml. The results indicate that the compound has potential to be used for treatment of several human and animal parasitic diseases.

• 出版日期1994-3
• 单位中山大学