The Impact of Atmospheric Pollutants on the Prevalence of Atopic Eczema in 6-7-Year-Old Schoolchildren in Spain; ISAAC Phase III

作者：Morales Suarez Varela Maria^*; Gallardo Juan Amparo; Garcia Marcos Luis; Gimeno Clemente Natalia; Lopez Silvarrey Varela Angel; Miner Canflanca Inaqui; Batlles Garrido Jose; Blanco Quiros Alfredo; Maria Busquets Monge Rosa; Dominguez Aurrecoechea Begona; Arnedo Pena Alberto; Gonzalez Diaz Carlos; Aguinaga Ontoso Ines; Martinez Gimeno Antonio; Llopis Gonzalez Agustin

来源：Iranian Journal of Allergy, Asthma and Immunology, 2013, 12(3): 220-227.

• Atmospheric Pollutants
• Atopic Eczema
• Phase III ISAAC Study

Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life with a high morbidity rate and severe economic burden. The objective of the present work was to analyse specific atmospheric pollutants (O-3, NO, PM10 and SO2) affecting the prevalence of diagnosed AE and its symptoms among 6-7-year-old schoolchildren. %26lt;br%26gt;The participants included 21311 schoolchildren aged 6-7 years from 8 Spanish regions, whose parents completed the ISAAC Phase III questionnaire to ascertain AE diagnosis and symptoms. The mean levels (mu g/m(3)) of O-3, NO, PM10 (particles 10 micrometers or less in diameter) and SO2 were determined in each geographical area participating in this study. %26lt;br%26gt;According to these mean levels, three levels of exposure to each pollutant were considered: level 1 (percentiles 0-25); level 2 (percentiles 26-74); level 3 (percentiles 75-100). Exposure to O-3 was associated with increased prevalence of rashes (exposure level 2, Odds Ratio (OR): 1.22, 95% Confidence Interval (95% CI): 1.02-1.45; level 3 OR: 1.33, 95% CI: 1.10-1.61) and diagnosed AE (level 2, OR: 1.27, 95% CI: 1.17-1.39; level 3 OR: 1.27, 95% CI: 1.15-1.41). An association was found between the level of NO and a drop in the prevalence of diagnosed AE (exposure level 2, OR: 0.88, 95% CI: 0.81-0.95; level 3 OR: 0.85, 95% CI: 0.74-0.97). There was also an association between the highest exposure level to PM10 and a reduced prevalence of rashes (level 3 OR: 0.42, 9 5 % CI: 0.22-0.81) and diagnosed AE (level 3 OR: 0.53, 95% CI: 0.38-0.75). %26lt;br%26gt;Future studies into exposure to O-3 and its relationship with allergic diseases may be conducted in order to prevent this association.

• 出版日期2013-9