An Eficient One-Pot Synthesis of 1,4-Dihydropyridines Catalyzed by Magnetic Nanocrystalline Fe3O4

作者:Yang Shu Hong; Zhao Fei Yang; Lu Hong Yan; Deng Jia; Zhang Zhan Hui*
来源:Journal of Heterocyclic Chemistry, 2012, 49(5): 1126-1129.
DOI:10.1002/jhet.953

摘要

An efficient approach for one-pot three-component reaction of aromatic amines, alpha,beta-unsaturated aldehydes and beta-keto esters using magnetic nanocrystalline Fe3O4 as a catalyst has been described. The corresponding 1,4-dihydropyridines are obtained in good yields under mild conditions. In addition, the catalyst can be recovered with a magnet and reused at least five consecutive cycles without appreciable loss of its catalytic activity.