Association between Infection Aspects in Women with Squamous Intraepithelial Lesions and Peniscopic Findings in Their Male Sexual Partners

作者：Ivkosic I Erceg^*; Habek D; Ferencak V; Tikvica A; Marijanovic I; Miskovic B

来源：Geburtshilfe und Frauenheilkunde, 2010, 70(3): 215-218.

DOI：10.1055/s-0029-1240913

• squamous intraepithelial lesions
• colposcopy
• peniscopy
• HPV

Purpose: To correlate colposcopy of women having squamous intraepithelial lesions (SIL) and peniscopic findings in their male sexual partners, to determine the prevalence of human papillomavirus (HPV) DNA in the male partners of women affected by SIL, and to assess the concordance of the viral group in the infected couple.
Patients and Methods: 27 females with different grade of SW were examined by cytology, colposcopy and histology and their male sexual partners underwent clinical examination, peniscopy and biopsy. HPV testing was performed for all.
Results: 50% of the sexual partners of women with low-grade squamous intraepithelial lesions (LSIL) were peniscopically negative. 36% of the male partners of women with high-grade squamous intraepithelial lesions (HSIL) were peniscopically negative. Clinical lesions were observed in 50 and 9% of the sexual partners of women with LSIL and HSIL, respectively, while subclinical lesions were found only in male partners of women with HSIL (45%). Sexual partners of women with LSIL enrolled ill our study were not HPV-positive. Male partners of patients with HSIL were HPV-positive in 63% cases with 59% being infected with high-risk viruses and 4% with low-risk HPV viruses. The same genotypes were found in 19% of couples, similarity in one genotype and difference in the other was found in 29.6% of couples, while complete discordance was found in 48% of couples. Highest concordance was achieved by high-risk types, especially type 16.
Conclusion: Male sexual partners of women with SIL lesions have penile lesions determined by peniscopical examination that are mostly associated with the presence of high-risk HPV in women with HSIL. High-risk HPV prevalence is found among male partners with clinical and especially subclinical penile manifestations. Concordance of the viral group in infected pair needs to be more elucidated.

• 出版日期2010-3