Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic

作者：De Paoli Marine; Perco Paul; Muehlberger Irmgard; Lukas Arno; Pandha Hardev; Morgan Richard; Feng Gui Jie; Marquette Christophe^*

来源：Biomarkers, 2015, 20(5): 328-337.

DOI：10.3109/1354750X.2015.1068867

• Biomarkers
• bladder cancer
• invasiveness
• recurrence

Context: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer.
Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer.
Materials and methods: Urinary biomarker concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis.
Results: A five-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set.
Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.

• 出版日期2015