An Efficient Catalyst System for the Synthesis of N-(p-benzoylaminoaryl)-N '-Boc Piperazines Under Microwave Conditions

作者：Reddy Mule S; Satyanarayana Peruri V V; Haribabu Bollikolla^*

来源：Letters in Organic Chemistry, 2012, 9(10): 739-744.

• N-(p-benzoylaminoaryl)-N '-Boc Piperazines
• amination
• palladium catalyst
• microwave

We have developed a new combination of catalyst system for the synthesis of N-(p-benzoylaminoaryl)-N'-Boc piperazines under microwave conditions (Biotage, 300 Watt) in the presence of sodium tert-butoxide and in DMF. The catalyst and ligand used are Tris (dibenzylideneacetone) dipalladium(0) and 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl (Dave Phos) respectively, the desired N-(p-benzoylaminoaryl)-N'-Boc Piperazines was obtained in good yields (80-92%).

• 出版日期2012-12