alpha-cyclodextrin-induced self-assembly of a double-hydrophilic block copolymer in aqueous solution

作者：Liu Jianhong; Sondjaja Herriyanto R; Tam Kam C^*

来源：Langmuir, 2007, 23(9): 5106-5109.

DOI：10.1021/la063365r

Double-hydrophilic poly(ethylene oxide)-b-poly(acrylic acid) (PEO-b-PAA) self-assembled into nanostructures in basic solution upon the addition of alpha-cyclodextrin (alpha-CD) as a result of the complexation between alpha-CD and PEO. The nanostructures produced were spherical in shape as observed by transmission electron microscopy (TEM) and possessed radii that were much larger than that of a single stretched polymeric chain. The ratio of R-g/R-h (where R-g is the z-average radius of gyration and R-h is the hydrodynamic radius) obtained from laser light scattering (LLS) was approximately similar to 1.0, and the aggregation number was similar to 4100. The zeta-potential of complex particle was -45 mV, suggesting that the particle possessed a stable negatively charged surface, attributed to ionized PAA segments. The above results suggested that the nanostructures formed in the PEO-b-PAA/alpha-CD solution at high pH were likely to be spherical vesicles.

• 出版日期2007-4-24
• 单位南阳理工学院