科研之友
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摘要
Considerable evidence shows that increased serum calcium levels are associated with metabolic disorders, cardiovascular disease, and increased mortality. This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in nondiabetic Korean subjects. A cross-sectional analysis was performed on 1096 subjects (mean age, 55.1 +/- 11.1 years; 36.1% women) undergoing a general health checkup. Serum biochemistry was analyzed including serum albumin-corrected calcium (Ca-c), insulin resistance (IR, using homeostasis model assessment [HOMA]), fibrinogen, and homocysteine. Compared with patients within the lowest Ca-c quartile, those with higher Ca-c levels had increased fibrinogen and homocysteine levels as well as an increased proportion of smoking, dyslipidemia, and HOMA-IR. Correlation analyses revealed linear relationships for Cac with fibrinogen and homocysteine in both genders. After adjustment for confounding factors, serum Cac was significantly associated with high fibrinogen (odds ratio [OR] for the highest vs the lowest quartile=1.76, 95% confidence interval [CI]=1.09-2.83, P=0.02) and homocysteine (OR=1.83, 95% CI=1.07-3.11, P=0.027). Multivariate regression models showed that Cac was linearly associated with fibrinogen (standardized b=0.14, P<0.001) and homocysteine (standardized beta=0.07, P=0.009). High normal calcium concentrations were independently associated with increased levels of fibrinogen and homocysteine. Further investigation is needed to validate whether slightly increased calcium levels within the normal range indicate a higher risk of cardiovascular disease.
- 出版日期2016-6
