Weighing the Proteasome for Covalent Modifications

作者:Birner Gruenberger Ruth; Breinbauer Rolf*
来源:Chemistry & Biology, 2015, 22(3): 315-316.
DOI:10.1016/j.chembiol.2015.03.003

摘要

Posttranslational modifications (PTMs) control protein function, but established peptide-based proteomic methods often fail to provide a comprehensive view of PTMs. In this issue of Chemistry & Biology, Gersch et al. describe an efficient combination of chromatographic separation and top-down mass spectrometry that together with an intuitive visualization tool allowed them to screen the proteasome for PTMs and covalently binding inhibitors.

  • 出版日期2015-3-19