ISOLATION OF CHICKEN-BEK AND A RELATED GENE - IDENTIFICATION OF STRUCTURAL VARIATION IN THE LIGAND-BINDING DOMAINS OF THE FGF-RECEPTOR FAMILY

作者：SATO M; KITAZAWA T; IWAI T; SEKI J; SAKATO N; KATO JY; TAKEYA T^*

来源：Oncogene, 1991, 6(7): 1279-1283.

cDNA clones carrying the chicken-bek gene and a related gene were isolated. Deducing the amino acid sequence of chicken-bek allowed us to predict that it encodes for a receptor tyrosine kinase related to the fibroblast growth factor (FGF) receptor, and that the chicken-bek gene and Cek3 are closely related. However, a significant structural difference was identified between chicken-bek and Cek3 within the putative extracellular region, in such a manner that the structure of the immunoglobulin-like domain was conserved. A probe specific to the altered structure detected mRNA in the tissues as did a probe common to bek and Cek3, indicating heterogeneity in the FGF-receptor family in a novel manner. Furthermore, another bek-like gene was isolated and the expressions of its mRNA and protein product were analysed in tissues and cultured cells.

• 出版日期1991-7