Glycosylation-directed quality control of protein folding

作者：Xu Chengchao; Ng Davis T W^*

来源：Nature Reviews Molecular Cell Biology, 2015, 16(12): 742-752.

DOI：10.1038/nrm4073

Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated in the endoplasmic reticulurn. These adducts have many biological functions, including, notably, their contribution to the maturation of glycoproteins. N-linked glycans are of oligomeric structure, forming configurations that provide blueprints to precisely instruct the folding of protein substrates and the quality control systems that scrutinize it. O-linked mannoses are simpler in structure and were recently found to have distinct functions in protein quality control that do not require the complex structure of N-linked glycans. Together, recent studies reveal the breadth and sophistication of the roles of these glycan-directed modifications in protein biogenesis.

• 出版日期2015-12