Binding of Eu-III to 1,2-Hydroxypyridinone-Modified Peptide Nucleic Acids

作者：de Leon Arnie R; Olatunde Abiola O; Morrow Janet R^*; Achim Catalina

来源：Inorganic Chemistry, 2012, 51(23): 12597-12599.

DOI：10.1021/ic301790v

Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu-III as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu-III excitation spectra and luminescence lifetime data are consistent with Eu-III bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution.

• 出版日期2012-12-3