AlphaB-crystallin regulates remyelination after peripheral nerve injury

作者：Lim Erin Mai F; Nakanishi Stan T; Hoghooghi Vahid; Eaton Shane E A; Palmer Alexandra L; Frederick Ariana; Stratton Jo A; Stykel Morgan G; Whelan Patrick J; Zochodne Douglas W; Biernaskie Jeffrey; Ousman Shalina S^*

来源：Proceedings of the National Academy of Sciences, 2017, 114(9): E1707-E1716.

DOI：10.1073/pnas.1612136114

• peripheral nerve injury
• remyelination
• Schwann cells
• alphaB-crystallin
• Wallerian degeneration

AlphaB-crystallin (alpha BC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (PNS) axons and Schwann cells. To determine what role this crystallin plays after peripheral nerve damage, we found that loss of aBC impaired remyelination, which correlated with a reduced presence of myelinating Schwann cells and increased numbers of nonmyelinating Schwann cells. The heat shock protein also seems to regulate the cross-talk between Schwann cells and axons, because expected changes in neuregulin levels and ErbB2 receptor expression after PNS injury were disrupted in the absence of aBC. Such dysregulations led to defects in conduction velocity and motor and sensory functions that could be rescued with therapeutic application of the heat shock protein in vivo. Altogether, these findings show that aBC plays an important role in regulating Wallerian degeneration and remyelination after PNS injury.

• 出版日期2017-2-28