A role of FCER1A and FCER2 polymorphisms in IgE regulation

作者：Sharma V; Michel S; Gaertner V; Franke A; Vogelberg C; von Berg A; Bufe A; Heinzmann A; Laub O; Rietschel E; Simma B; Frischer T; Genuneit J; Potaczek D P; Kabesch M^*

来源：Allergy, 2014, 69(2): 231-236.

DOI：10.1111/all.12336

• FCER1A
• FCER2
• fine mapping
• genetic variants
• IgE

BackgroundBoth FCER2 and FCER1A encode subunits of IgE receptors. Variants in FCER1A were previously identified as major determinants of IgE levels in genome-wide association studies. %26lt;br%26gt;MethodsHere we investigated in detail whether FCER2 polymorphisms affect IgE levels alone and/or by interaction with FCER1A polymorphisms. To cover the genetic information of FCER2, 21 single-nucleotide polymorphisms (SNPs) were genotyped by Illumina HumanHap300 BeadChip (5 SNPs) and the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS; 14 SNPs) in at least 1303 Caucasian children (651 asthmatics) (ISAAC II/ MAGICS population); genotypes of two SNPs were imputed. %26lt;br%26gt;ResultsSNP rs3760687 showed the most consistent effect on total serum IgE levels (b [SE]=-0.38 [0.16]; P=0.016), while FCER2 polymorphisms in general were predominantly associated with mildly-to-moderately increased IgE levels (50th and 66th percentiles). Gene-by-gene interaction analysis suggests that FCER2 polymorphism rs3760687 influences IgE levels mainly in individuals not homozygous for the risk allele of FCER1A polymorphism rs2427837, which belongs to the major IgE-determining tagging bin in the population. %26lt;br%26gt;ConclusionFCER2 polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of FCER1A SNP rs2427837.

• 出版日期2014-2