alpha-Tocopherol and lipid profiles in plasma and the expression of alpha-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters

作者：Laothong Umawadee; Pinlaor Porntip; Boonsiri Patcharee; Hiraku Yusuke; Khoontawad Jarinya; Hongsrichan Nuttanan; Charoensuk Lakhanawan; Pinlaor Somchai^*

来源：Parasitology International, 2013, 62(2): 127-133.

DOI：10.1016/j.parint.2012.11.002

• Opisthorchis viverrini
• Hamster
• alpha-Tocopherol
• Lipid profile
• Lipoprotein

Opisthorchis viverrini infection induces inflammation-mediated oxidative stress and liver injury, which may alter alpha-tocopherol and lipid metabolism. We investigated plasma alpha-tocopherol and lipid profiles in hamsters infected with O. viverrini. Levels of alpha-tocopherol, cholesterol, and low-density lipoprotein increased in the acute phase of infection. In the chronic phase, alpha-tocopherol decreased, while triglyceride and very low-density lipoprotein increased. Notably, high-density lipoprotein decreased both in the acute and chronic phases. In the liver, cholesteryl oleate, triolein, and oleic acid decreased in the acute phase, and increased in the chronic phase. Such chronological changes were negatively correlated with the plasma alpha-tocopherol level. The expression of alpha-tocopherol-related molecules, ATP-binding cassette transporter A1 (ABCA1) and alpha-tocopherol transfer protein, increased throughout the experiment. These results suggest that O. viverrini infection profoundly affects on lipid and alpha-tocopherol metabolism in due course of infection.

• 出版日期2013-4