Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: Does-7/7q-detection by FISH have prognostic value?

作者：Adema Vera; Maria Hernandez Jesus; Abaigar Maria; Lumbreras Eva; Such Esperanza; Calull Anna; Dominguez Esther; Arenillas Leonor; Mallo Mar; Cervera Jose; Marugan Isabel; Tormo Mar; Garcia Francisca; Gonzalez Teresa; Luno Elisa; Sanzo Carmen; Luisa Martin Maria; Fernandez Manuela; Costa Dolors; Blazquez Beatriz; Barrena Beatriz; Marco Fernando; Batlle Ana; Buno Ismael; Martinez Laperche Carolina; Noriega Victor; Collado Rosa; Ivars David; Carbonell Felix

来源：Leukemia Research, 2013, 37(4): 416-421.

DOI：10.1016/j.leukres.2012.12.010

• MDS
• Cytogenetics
• FISH
• Chromosome

Chromosomal abnormalities are detected in 40-60% of patients with de novo myelodysplastic syndromes (MDS). This study used the FISH technique in 773 patients with de novo MDS without evidence of monosomy 7 (-7) or 7q deletion (7q-) by conventional G-banding cytogenetics (CC) to analyze their prognostic impact by FISH alone. FISH detected -7/7q- in 5.2% of patients. Presence of -7/7q- was associated with shorter overall survival than absence of such aberrations. Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC.

• 出版日期2013-4