A Reactive Oxygen/Nitrogen Species Sensor Fabricated from an Electrode Modified with a Polymerized Iron Porphyrin and a Polymer Electrolyte Membrane

作者：Matsuoka Ryo^*; Kobayashi Chihiro; Nakagawa Atsushi; Aoyagi Shigeo; Aikawa Tatsuo; Kondo Takeshi; Kasai Shigenobu; Yuasa Makoto

来源：Analytical Sciences, 2017, 33(8): 911-915.

DOI：10.2116/analsci.33.911

• Anion radicals (O-2(-center dot))
• nitric oxide (NO)
• sensor
• porphyrin
• reactive oxygen species
• reactive nitrogen species
• modified electrode
• electrochemical

We have developed an electrochemical reactive oxygen/nitrogen species sensor that can detect superoxide anion radicals (O-2(-center dot)) and nitric oxide (NO). The reactive oxygen/nitrogen species sensor was fabricated by surface modification of an electrode with polymerized iron tetrakis(3-thienyl)porphyrin (FeT3ThP), and it can detect either O-2(-center dot) or NO by switching the applied potential. Furthermore, we fabricated a sensor with improved selectivity by coating a Nafion (R) film onto the poly(FeT3ThP)-modified electrode. An interference current caused by NO2- was seen for the poly(FeT3ThP)-modified electrode, while the interference current was significantly reduced at the Nafion (R)/poly(FeT3ThP)-modified electrode, leading to improved selectivity for NO detection. The current response at the Nafion (R)/poly(FeT3ThP)-modified electrode exhibited good linearity in the O-2(-center dot). and NO concentration ranges 1.3 - 4.1, and 0.5 - 10 mu M, respectively. The Nafion (R)/ poly(FeT3ThP)-modified and poly(FeT3ThP)-modified electrodes are highly versatile, because these electrodes can detect either O-2(-center dot) or NO by switching the applied potential. Since the Nafion (R)/poly(FeT3ThP)-modified and poly(FeT3ThP)-modified electrodes contain no bio-derived compounds, the reactive oxygen/nitrogen species sensor should be safe even when it is used in vivo.

• 出版日期2017-8