APOE epsilon 4 is a high-risk factor for Alzheimer's disease in the Mongolian population

作者：Huriletemuer; Wang, Binbin; Wang, Jing; Wang, Guan; Zhang, Chunyu; Zhao, Shigang; Zhou, Sirui; Ma, Xu^*; Wang, De Sheng

来源：Journal of the Neurological Sciences, 2010, 288(1-2): 167-169.

DOI：10.1016/j.jns.2009.08.058

• Alzheimer's disease
• Apolipoprotein E
• Mongolian

To determine the relationship between apolipoprotein E (APOE) epsilon 4 and sporadic Alzheimer's disease (SAD) in the Mongolian population in China, we examined 106 Mongolian SAD patients in China and 100 Mongolian healthy controls. All subjects were genotyped for APOE.
The odds ratio (OR) for developing SAD was significantly increased in carriers of the APOE 0 allele compared with APOE epsilon 4 non-carriers (chi(2) = 5.59, df = 1, P = 0.018, OR = 1.84, 95% CI 1.02-3.31).
Our findings suggested that APOE epsilon 4 is a high-risk factor for AD in the Mongolian population in China. The present study is the first to establish the relationship between APOE epsilon 4 and SAD in the Mongolian population.

• 出版日期2010-1-15
• 单位中国医学科学院北京协和医院; 内蒙古医科大学; 哈尔滨医科大学; 天津中医药大学; 国家卫生计生委科学技术研究所