A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

作者：Tyagi Rahul; Shimpukade Bharat; Blattermann Stefanie; Kostenis Evi; Ulven Trond^*

来源：Medchemcomm, 2012, 3(2): 195-198.

DOI：10.1039/c1md00231g

A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions.

• 出版日期2012-2