A disease-specific activity score for Thromboangiitis obliterans

作者：Fazeli Bahare; Ravari Hassan^*

来源：Vascular, 2014, 22(5): 336-340.

DOI：10.1177/1708538113516315

• Thromboangiitis obliterans
• Buerger's disease
• disease activity
• vasculitis

Introduction: The aim of this study was to find a disease-specific activity score for Thromboangiitis obliterans (TAO).
Methods: About 173 admission records from 125 patients with TAO over the period 2005-2011 were evaluated. The outcome of the patients was categorized as saved-limb or limb-loss. The risk of limb loss associated with each clinical sign or symptom and complete blood count (CBC) data were then assessed. This risk assessment value was multiplied by 100 to obtain the percentage risk, which was then considered to be the risk score. The receiver operating characteristic (ROC) curve was used for demonstrating cut-offs for each score. The reliability of the risk score was evaluated using a split-half reliability test. The divergent validity of the risk score was tested using the Pearson correlation coefficient between the total scores of the patients with and without limb loss.
Results: The maximum possible clinical and CBC scores were 221 and 180, respectively, giving a maximum total score of 401. The cut-offs for clinical, laboratory and total score were 115, 75 and 213, respectively.
Conclusion: Further cohort studies for evaluating the efficacy of different treatments for limb salvage of TAO patients based on these score are suggested.

• 出版日期2014-10