Population biology of the human restricted pathogen, Streptococcus pyogenes

作者：Bessen Debra E^*

来源：Infection, Genetics and Evolution, 2009, 9(4): 581-593.

DOI：10.1016/j.meegid.2009.03.002

• Streptococcus
• Group A streptococcus
• Streptococcus pyogenes
• Population biology
• Population genetics
• Epidemiology
• Ecology
• Evolution

Streptococcus pyogenes, also referred to as beta-hemolytic group A streptococci, are strictly human pathogens with a global distribution and high prevalence of infection. The organisms are characterized by high levels of genetic recombination, extensive strain diversity, and a narrow habitat. This review highlights many key features of the population genetics and molecular epidemiology of this biologically diverse bacterial species, with special emphasis on ecological subdivisions and tissue-specific infections, strain diversity and population dynamics in communities, selection pressures arising from the specific host immune response and antibiotic exposure, and within-host selection during the course of invasive disease.

• 出版日期2009-7