A Fast and Highly Efficient Protocol for Reductive Amination of Aromatic Aldehydes Using NaBH4 and Isoxazole Amines in an Ionic Liquid Medium

作者：Eligeti Rajanarendar^*; Atthunuri Siva Rami Reddy; Samala Raju; Shaik Firoz Pasha; Kundur Govardhan Reddy

来源：Chinese Journal of Chemistry, 2011, 29(4): 769-772.

DOI：10.1002/cjoc.201190155

• ionic liquid
• green chemistry reductive amination
• 1-methylimidazolium tetrafluoroborate
• isoxazole amine

Reductive amination of aromatic aldehydes using NaBH4 and isoxazole amines is carried out in a Bronsted acidic ionic liquid 1-methylimidazolium tetrafluoroborate [(HMIm)BF4]. The ionic liquid plays dual roles of solvent as well as catalyst for the efficient transformation of aromatic aldehydes to heterocyclic substituted amines in excellent yields without any undesired side product formation. The newly synthesized compounds (3, 6 and 7) were characterized by IR, H-1 NMR and mass spectral techniques.

• 出版日期2011-4