Airway Response to Exercise by Forced Oscillations in Asthmatic Children

作者：Schweitzer Cyril; Ben Abdelkrim Imen; Ferry Helene; Werts Frederique; Varechova Silvia; Marchal Francois^*

来源：Pediatric Research, 2010, 68(6): 537-541.

DOI：10.1203/PDR.0b013e3181f851d2

Forced expiratory volume in 1 s (FEV(1)) detection of exercise-induced bronchoconstriction (EIB) to identify asthma has good specificity but rather low sensitivity. The aim was to test whether sensitivity may be improved by measuring respiratory resistance (RRs) by the forced oscillation technique (FOT). Forty-seven asthmatic and 50 control children (5-12 y) were studied before and after running 6 mm on a treadmill. RRS in inspiration (RRsi) and expiration (RRse), FEV(1) and RRsi response to a deep inhalation (DI) were measured before and after exercise. In asthmatics versus controls, exercise induced significantly larger increases in RRsi (p < 0.001) and larger decreases in FEV(1) (p = 0.004). Asthmatics but not controls showed more bronchodilation by DI after exercise (p = 0.02). At specificity >0.90, sensitivity was 0.53 with 25% increase RRSi and 0.45 with 27% increase RRse or 5% decrease FEV(1). It is concluded that the FOT improves sensitivity of exercise challenge, and the RRsi response to DI may prove useful in identifying the mechanism of airway obstruction. (Pediatr Res 68: 537-541, 2010)

• 出版日期2010-12