A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans from alpha-oxo ketene dithioacetals and propargyl alcohols via domino coupling/annulations

作者：Yang Xiaobing; Hu Fangzhong^*; Di Hongjing; Cheng Xinxin; Li Dan; Kan Xiaoli; Zou Xiaomao; Zhang Qichun

来源：Organic and Biomolecular Chemistry, 2014, 12(44): 8947-8951.

DOI：10.1039/c4ob01300j

A convenient base-mediated strategy to synthesize 3-aryol-4-methyl (or benzyl)-2-methylthio furans 2 (trisubstituted furans) has been developed through the domino coupling/annulations between available alpha-oxo ketene dithioacetals 1 and propargyl alcohols. In this strategy, these types of bases play an important role in driving the domino coupling reaction of propargyl alcohols and further intramolecular annulations to realize the target compounds. The possible mechanism for the formation of the various products is believed to involve the generation of allenes 7, followed by intramolecular annulations.

• 出版日期2014
• 单位南开大学; 南阳理工学院