Alpha-Synuclein Repeat Variants and Survival in Parkinson%26apos;s Disease

作者：Chung Sun Ju; Biernacka Joanna M; Armasu Sebastian M; Anderson Kari; Frigerio Roberta; Aasly Jan O; Annesi Grazia; Bentivoglio Anna Rita; Brighina Laura; Chartier Harlin Marie Christine; Goldwurm Stefano; Hadjigeorgiou Georgios; Jasinska Myga Barbara; Jeon Beom Seok; Kim Yun Joong; Krueger Rejko; Lesage Suzanne; Markopoulou Katerina; Mellick George; Morrison Karen E; Puschmann Andreas; Tan Eng King; Crosiers David; Theuns Jessie; Van Broeckhoven Christine

来源：Movement Disorders, 2014, 29(8): 1053-1057.

DOI：10.1002/mds.25841

• Parkinson%26apos
• s disease
• alpha-synuclein
• gene
• survival
• association

Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson%26apos;s disease (PD). %26lt;br%26gt;Methods: Investigators from the Genetic Epidemiology of Parkinson%26apos;s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. %26lt;br%26gt;Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). %26lt;br%26gt;Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein%26apos;s role in disease progression and long-term outcomes are needed.

• 出版日期2014-7