Antimutagenesis of multiphytoadaptogene in yeast Saccharomyces

作者：Kurennaya O N^*; Karpova R V; Bocharova O A; Kazeev I V; Bocharov E V; Korolev V G

来源：Russian Journal of Genetics, 2013, 49(12): 1190-1194.

DOI：10.1134/S1022795413120053

Multiphytoadaptogene (MPA) consists of plant extracts components including adaptogenes. Genotoxicity analysis revealed the antimutagenic activity of MPA. MPA decreased the direct mutations frequency in ADE4-ADE8 loci induced by UV radiation and nitrous acid by 3.7 and 33 times, respectively. The lethal effect of UV radiation was inhibited when the preparation preparation MFA was used on complete medium with ethanol. MPA had no effect on replicative mutagenesis. At the same time it depressed mutagenesis caused by repair errors. The data obtained suggest the antimutagenic activity of multiphytoadaptogene is associated with postreplicative repair activation.

• 出版日期2013-12