Association between hepatic cholesterol and oleic acid in the liver of rats treated with partially hydrogenated vegetable oil

作者：Ferreira de Castro Gabriela Salim; de Almeida Bianca Bellizzi; Leonardi Daphne Santoro; Ovidio Paula Payao; Jordao Alceu Afonso

来源：Revista de Nutricao-Brazilian Journal of Nutrition, 2012, 25(1): 45-56.

• Fatty liver
• Fats, saturated
• Lipoproteins
• Trans fatty acids

Objective
The aim of the present study was to investigate the lipid profiles of the hepatic and adipose tissues of Wistar rats treated for 21 days with a diet high in saturated fat (high saturated fat, n=6) or high in hydrogenated fat, that is, having 50% partially hydrogenated vegetable oil in its composition (high hydrogenated fat, n=6), and compare them to those of a control group (control group, n=6).
Methods
Adipose tissue and total hepatic fat were higher in the saturated fat group than in the hydrogenated fat group. Hepatic lipid peroxidation was greatest in the saturated fat group, with consequent lower hepatic vitamin E and A levels. In contrast, serum vitamin A was highest in the saturated fat group. Analysis of hepatic lipid fractions found more cholesterol and less high density lipoprotein-cholesterol in the hydrogenated fat group. The hydrogenated fat group had the highest levels of triacylglycerols, followed by the saturated fat group.
Results
Significant amounts of trans fatty acids were detected in the hepatic and adipose tissues of the hydrogenated fat group. Among the identified fatty acids, 18:1n9 had a higher positive association with hepatic cholesterol and triacylglycerols, and a higher negative association with high density lipoprotein-cholesterol. Partially hydrogenated vegetable oil promotes greater accumulation of cholesterol and triacylglycerols in the liver than saturated fats.
Conclusion
Trans fatty acids were incorporated into hepatocytes and adipocytes in a highly efficient manner.

• 出版日期2012-2