Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

作者：Monticelli Laurel A; Buck Michael D; Flamar Anne Laure; Saenz Steven A; Wojno Elia D Tait; Yudanin Naomi A; O**orne Lisa C; Hepworth Matthew R; Tran Sara V; Rodewald Hans Reimer; Shah Hardik; Cross Justin R; Diamond Joshua M; Cantu Edward; Christie Jason D; Pearce Erika L; Artis David

来源：Nature Immunology, 2016, 17(6): 656-+.

DOI：10.1038/ni.3421

Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after activation by cell-extrinsic factors such as host-derived cytokines. However, the cell-intrinsic metabolic pathways that control ILC2 function are undefined. Here we demonstrate that expression of the enzyme arginase-1 (Arg1) during acute or chronic lung inflammation is a conserved trait of mouse and human ILC2s. Deletion of mouse ILC-intrinsic Arg1 abrogated type 2 lung inflammation by restraining ILC2 proliferation and dampening cytokine production. Mechanistically, inhibition of Arg1 enzymatic activity disrupted multiple components of ILC2 metabolic programming by altering arginine catabolism, impairing polyamine biosynthesis and reducing aerobic glycolysis. These data identify Arg1 as a key regulator of ILC2 bioenergetics that controls proliferative capacity and proinflammatory functions promoting type 2 inflammation.

• 出版日期2016-6